Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: A CARE compliant case report.

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dc.contributor.authorReynel, María B.
dc.contributor.authorVillegas, Yván
dc.contributor.authorKiene, Helmut
dc.contributor.authorWerthmann, Paul G.
dc.contributor.authorKienle, Gunver S.
dc.date.accessioned2024-05-23T18:53:45Z
dc.date.available2024-05-23T18:53:45Z
dc.date.digitized2020-09-09 02:24:45
dc.date.issued2018
dc.description.abstract<p><strong>Rationale</strong>: Carcinoma in situ (CIS) of the uterine cervix is a premalignant condition of squamous epithelium. The standard treatments are excision and ablation procedures; for women with positive margins, hysterectomy is recommended.</p> <p><strong>Patient concerns</strong>: A 47-year-old Peruvian woman with recurrent candidal vaginitis had been diagnosed with colpocervicitis and squamous metaplasia 8 years ago, which were not treated.</p> <p><strong>Diagnoses</strong>: The patient was diagnosed with CIS after cervical conization procedure. She refused radical hysterectomy and opted for integrative medicine treatment.</p> <p><strong>Interventions</strong>: She was treated with intralesional and subcutaneous Viscum album L. extract (VAE) injections. VAE is a widely used herbal cancer treatment with cytotoxic, apoptogenic, and immunological effects, but it has not been investigated in cervical CIS.</p> <p><strong>Outcomes</strong>: Ending month 5 of treatment, complete remission of cervical CIS was observed. The patient is still in remission after 30 months (until publication).</p> <p><strong>Lessons</strong>: This is the first report on complete remission of cervical CIS after intralesional and subcutaneous injection with VAE. Prospective studies should evaluate to what degree the treatment effect is reproducible.</p> <p><strong>Abbreviations</strong>: CIN = cervical intraepithelial neoplasia, CIS = carcinoma in situ, HPV = human papillomavirus, IL = interleukin, ML = mistletoe lectins, Pap = Papanicolaou, VAE = Viscum album L. extract.</p> <p><strong>Keywords</strong>: case report, cervical carcinoma in situ, cervical intraepithelial neoplasia, complete remission, european mistletoe, fraxini, Viscum album L</p> <p><strong>Citation</strong>: Reynel, M., Villegas, Y., Kiene, H., Werthmann, P. G., &amp; Kienle, G. S. (2018). Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: A CARE compliant case report. <em>Medicine</em>, <em>97</em>(48), e13420. <a href="https://doi.org/10.1097/MD.0000000000013420" target="_blank">https://doi.org/10.1097/MD.0000000000013420</a> </p>
dc.description.notesfixed
dc.identifier.citationReynel, M., Villegas, Y., Kiene, H., Werthmann, P. G., & Kienle, G. S. (2018). Intralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: A CARE compliant case report. Medicine, 97(48), e13420. https://doi.org/10.1097/MD.0000000000013420
dc.identifier.doihttps://doi.org/10.1097/MD.0000000000013420
dc.identifier.externalUrl/library/2020/8/13/intralesional-and-subcutaneous-application-of-viscum-album-l-european-mistletoe-extract-in-cervical-carcinoma-in-situ
dc.identifier.urihttps://hdl.handle.net/20.500.14430/407
dc.subject.otherCervical Cancer
dc.subject.otherCarcinoma-in-Situ Cervix
dc.subject.otherCandidal Infection
dc.subject.otherEuropean mistletoe
dc.subject.otherComplete remission
dc.titleIntralesional and subcutaneous application of Viscum album L. (European mistletoe) extract in cervical carcinoma in situ: A CARE compliant case report.
dspace.entity.typePublication
oaire.citation.titleMedicine
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