A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment: A case report

dc.contributor.authorWerthmann, Paul G.
dc.contributor.authorKindermann, Lothar
dc.contributor.authorKienle, Gunver S.
dc.date.accessioned2024-05-23T18:54:28Z
dc.date.available2024-05-23T18:54:28Z
dc.date.digitized2021-03-14 20:46:31
dc.date.issued2018
dc.description.abstract<p><strong>Background</strong>: Merkel cell carcinoma (MCC) is a rare, aggressive, neuroendocrine skin tumor with frequent local recurrence, lymph node involvement, distant metastasis, and a high mortality rate. Viscum album extracts (VAE) are a widely used adjunct in cancer treatment and show cytotoxic and immune-modulating effects. <strong>Case presentation</strong>: A 64-year-old woman was diagnosed with a MCC of the left forearm. In the following course of 21 years, she experienced 4 episodes of lymph node relapse (axillary, submandibular, axillary, clavicular). All lesions were surgically excised. The patient declined chemotherapy and radiation and opted for adjuvant treatment with local subcutaneous VAE injections. Currently—21 years after first diagnosis and 9.5 years after the last relapse—the patient is tumor-free, in good health, and without functional limitations. <strong>Conclusion</strong>: The presented case shows long-time survival in a patient with MCC treated with surgery and VAE injections. The immune system plays a key role in tumorigenesis of MCC. VAE enhances several immune pathways and might therefore contribute to immunologic tumor control in MCC. The role of VAE in MCC should further be investigated.</p> <p><strong>Keywords</strong>: Merkel cell carcinoma, Viscum album, Immune stimulation, Tumor control</p> <p><strong>Citation</strong>: Werthmann, P. G., Kindermann, L., &amp; Kienle, G. S. (2018). A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment: A case report. <em>Complementary Therapies in Medicine</em>, <em>38</em>, 58–60. <a href="https://doi.org/10.1016/j.ctim.2018.04.001" target="_blank">https://doi.org/10.1016/j.ctim.2018.04.001</a></p>
dc.description.notesfixed
dc.identifier.citationWerthmann, P. G., Kindermann, L., & Kienle, G. S. (2018). A 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment: A case report. Complementary Therapies in Medicine, 38, 58–60. https://doi.org/10.1016/j.ctim.2018.04.001
dc.identifier.doihttps://doi.org/10.1016/j.ctim.2018.04.001
dc.identifier.externalUrl/library/2021/3/8/a-21-year-course-of-merkel-cell-carcinoma-with-adjuvant-viscum-album-extract-treatment-a-case-report
dc.identifier.urihttps://hdl.handle.net/20.500.14430/441
dc.subject.otherImmune stimulation
dc.subject.otherMerkel cell carcinoma
dc.subject.otherTumor control
dc.subject.otherViscum album
dc.subject.otherskin tumors
dc.titleA 21-year course of Merkel cell carcinoma with adjuvant Viscum album extract treatment: A case report
dspace.entity.typePublication
oaire.citation.titleComplementary Therapies in Med
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