Effectiveness of a homeopathic complex medicine in infantile colic: A randomized multicenter study.

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dc.contributor.authorRaak, Christa
dc.contributor.authorKrueger, Peter
dc.contributor.authorKlement, Petra
dc.contributor.authorDe Jaegere, Sabine
dc.contributor.authorWeber, Stephan
dc.contributor.authorKeller, Thomas
dc.contributor.authorIlyenko, Lydia
dc.contributor.authorMartin, David
dc.contributor.authorOstermann, Thomas
dc.date.accessioned2025-07-12T22:28:11Z
dc.date.available2025-07-12T22:28:11Z
dc.date.issued2019-08
dc.description.abstractInfantile colic is a common benign disease occurring in early infancy that may have a great impact on family life. In the present study, the effectiveness and safety of the complex homeopathic medicine Enterokind was compared with Simethicone for treating infantile colic. Current data were drawn from a prospective, multicenter, randomized, open-label, controlled clinical trial that was conducted in 2009 in 3 Russian outpatient clinics. Children received either Enterokind (Chamomilla D6, Cina D6, Colocynthis D6, Lac defloratum D6 and Magnesium chloratum D6) or Simethicone. Data from infants ≤ 6 months with infantile colic are presented here. The main outcomes assessments were the change of total complaints score (maximum 17 points) and total objective symptoms score (maximum 22 points) after 10 days of treatment. Data from 125 infants ≤ 6 months with infantile colic were analyzed. The differences in total complaints and objective symptoms scores between baseline and day 10, estimated from the ANCOVA model, were found to be highly significant (p < 0.0001; ITT) in favor of Enterokind, both for complaints (Δ=-2.38; 95% confidence interval (CI): [-2.87; -1.89]) and for objective symptoms (Δ=-2.07; 95% CI: [-2.65; -1.49]). 1 adverse event (AE), vomiting, occurred under Enterokind and was rated to be unlikely related to it; 4 AEs occurred under Simethicone. All AEs were non-serious. The current study indicates that Enterokind is an effective and safe homeopathic treatment for functional intestinal colic in infants ≤ 6 months.
dc.identifier.citationRaak, C., Krueger, P., Klement, P., De Jaegere, S., Weber, S., Keller, T., Ilyenko, L., Martin, D., & Ostermann, T. (2019). Effectiveness of a homeopathic complex medicine in infantile colic: A randomized multicenter study. Complementary Therapies in Medicine, 45, 136–141. https://doi.org/10.1016/j.ctim.2019.05.026
dc.identifier.doihttps://doi.org/10.1016/j.ctim.2019.05.026
dc.identifier.issn0965-2299
dc.identifier.other31331550
dc.identifier.urihttps://hdl.handle.net/20.500.14430/784
dc.language.isoen
dc.subjectClinical trial
dc.subjectEnterokind
dc.subjectHomeopathic complex medicine
dc.subjectInfantile colic
dc.subject.meshChild, Preschool
dc.subject.meshChild
dc.subject.meshClinical Trials as Topic
dc.subject.meshColic
dc.subject.meshHomeopathy
dc.subject.meshInfant
dc.subject.meshInfant, Newborn
dc.subject.meshProspective Studies
dc.subject.meshSimethicone
dc.subject.otherClinical trials
dc.subject.otherHomeopathic medicine
dc.subject.otherInfantile colic
dc.titleEffectiveness of a homeopathic complex medicine in infantile colic: A randomized multicenter study.
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleComplementary Therapies in Med
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