Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract: A case report
dc.contributor.author | Werthmann, Paul G. | |
dc.contributor.author | Hintze, Alexander | |
dc.contributor.author | Kienle, Gunver S. | |
dc.date.accessioned | 2024-05-23T18:54:33Z | |
dc.date.available | 2024-05-23T18:54:33Z | |
dc.date.digitized | 2021-03-14 20:48:25 | |
dc.date.issued | 2017 | |
dc.description.abstract | <p class="" style="white-space:pre-wrap;"><strong>Introduction</strong>: Metastatic malignant cutaneous melanoma (MCM)—a highly immunogenic cancer—typically has a poor prognosis. Viscum album extracts (VAEs) have strong immune-stimulating, apoptogenic, and cytotoxic effects.</p><p class="" style="white-space:pre-wrap;"><strong>Case presentation</strong>: A 66-year-old MCM patient with newly diagnosed lymph node metastases opted for sole VAE treatment. VAEs were initially applied subcutaneously, and then later in exceptionally high, fever-inducing doses, both intravenously and intralesionally. The metastases shrunk over the following months, and after 2 years, all lesions had completely remitted (regional and hilar lymph nodes). The patient has been tumor free for 3.5 years at the time of publication (and for 5 years since initiation of intensified VAE treatment). Besides fever and flu-like symptoms, no side effects occurred.</p><p class="" style="white-space:pre-wrap;"><strong>Discussion</strong>: We presume that VAE triggered an increased release of tumor-associated antigens, enhanced immunologic recognition, and increased immune response against the tumor tissue and induced tumor remission.</p><p class="" style="white-space:pre-wrap;"><strong>Abbreviations</strong>: AJCC = American Joint Committee on Cancer, BRAF = rapidly growing fibrosarcoma type B gene, FDG = Fludeoxyglucose (18F), MCM = malignant cutaneous melanoma, ML = mistletoe lectin, PET-CT = positron emission tomography–computed tomography, UICC = Union internationale contre le cancer, VAE = Viscum album extracts, VT = viscotoxin.</p><p class="" style="white-space:pre-wrap;"><strong>Keywords</strong>: complete remission, fever, malignant cutaneous melanoma, Mistletoe, Viscum album extract</p><p class="" style="white-space:pre-wrap;"><strong>Citation</strong>: Werthmann, P. G., Hintze, A., & Kienle, G. S. (2017). Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract: A case report. <em>Medicine</em>, <em>96</em>(46), e8731. <a href="https://doi.org/10.1097/MD.0000000000008731" target="_blank">https://doi.org/10.1097/MD.0000000000008731</a></p> | |
dc.description.notes | fixed | |
dc.identifier.citation | Werthmann, P. G., Hintze, A., & Kienle, G. S. (2017). Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract: A case report. Medicine, 96(46), e8731. https://doi.org/10.1097/MD.0000000000008731 | |
dc.identifier.doi | https://doi.org/10.1097/MD.0000000000008731 | |
dc.identifier.externalUrl | /library/2021/3/8/complete-remission-and-long-term-survival-of-a-patient-with-melanoma-metastases-treated-with-high-dose-fever-inducing-viscum-album-extract-a-case-report | |
dc.identifier.uri | https://hdl.handle.net/20.500.14430/444 | |
dc.subject.other | malignant cutaneous melanoma | |
dc.subject.other | Viscum album extract | |
dc.subject.other | Complete remission | |
dc.subject.other | Fever | |
dc.subject.other | Mistletoe | |
dc.title | Complete remission and long-term survival of a patient with melanoma metastases treated with high-dose fever-inducing Viscum album extract: A case report | |
dspace.entity.type | Publication | |
oaire.citation.title | Medicine |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Werthmann_Complete remission and long-term survival_2017_medi-96-e8731.pdf
- Size:
- 1.38 MB
- Format:
- Adobe Portable Document Format