Complete, Durable Remission of Advanced Hepatocellular Carcinoma under Treatment with Viscum album Extracts: A Case Report. ABSTRACT

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dc.contributor.authorOrange, Maurice
dc.contributor.authorPoidimani, Nicoletta
dc.contributor.authorCrosignani, Andrea
dc.contributor.authorWerthmann, Paul G
dc.contributor.authorBertotto, Corrado
dc.date.accessioned2024-11-09T16:31:56Z
dc.date.available2024-11-09T16:31:56Z
dc.date.issued2022
dc.description.abstractHepatocellular carcinoma (HCC) is the third leading cause of cancer deaths. Early-stage disease is treated with curative intent, but most patients present with advanced HCC, which carries a poor prognosis. Viscum album extracts (VAE) are used by cancer patients as an adjunct treatment or palliation. A 51-year-old female presented with relapsing multifocal HCC. She declined palliative treatment and commenced intravenous VAE treatment in conjunction with intravenous hepato-protective L-ornithine-L-aspartate (LOLA). She experienced a significant improvement of life-quality and performance status. After 3 months, a significant regression was noted on computerized tomography, and α-fetoprotein was in normal range. Imaging 11 months later confirmed a complete regression. The VAE and LOLA treatment continues to date. The patient had no other cancer-directed therapy. The regression is sustained for more than 5 years at publication, confirmed by regular imaging and serology. The patient is experiencing an unrestricted quality of life. Complete regression of advanced HCC is rare. Responses of HCC to VAE treatment have been reported before. However, this is the first documented case with a complete and durable regression of an HCC under treatment with VAE. Further studies should evaluate VAE treatment in HCC, especially when administered in forms as reported here.
dc.identifier.citationOrange, M., Poidimani, N., Crosignani, A., Werthmann, P. G., & Bertotto, C. (2022). Complete, Durable Remission of Advanced Hepatocellular Carcinoma under Treatment with Viscum album Extracts: A Case Report. Complementary Medicine Research, 29(6), 483–491. https://doi.org/10.1159/000525409
dc.identifier.doihttps://doi.org/10.1159/000525409
dc.identifier.issn2504-2106
dc.identifier.orcid0000-0001-5678-9440
dc.identifier.other35764068
dc.identifier.urihttps://hdl.handle.net/20.500.14430/732
dc.language.isoen
dc.subjectComplete remission
dc.subjectHepatitis C
dc.subjectHepatocellular carcinoma
dc.subjectL-Ornithine-L-aspartate
dc.subjectViscum album
dc.subjecthepatitus
dc.titleComplete, Durable Remission of Advanced Hepatocellular Carcinoma under Treatment with Viscum album Extracts: A Case Report. ABSTRACT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleComplement Med Res
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