Preclinical and Clinical Effects of Mistletoe against Breast Cancer

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dc.contributor.authorMarvibaigi, Mohsen
dc.contributor.authorSupriyanto, Eko
dc.contributor.authorAmini, Neda
dc.contributor.authorAbdul Majid, Fadzilah Adibah
dc.contributor.authorJaganathan, Saravana Kumar
dc.date.accessioned2024-05-23T18:53:32Z
dc.date.available2024-05-23T18:53:32Z
dc.date.digitized2020-06-25 01:03:00
dc.date.issued2014
dc.description.abstract<p>Breast cancer is among the most frequent types of cancer in women worldwide. Current conventional treatment options are accompanied by side effects. Mistletoe is amongst the important herbal medicines traditionally used as complementary remedies. An increasing number of studies have reported anticancer activity of mistletoe extracts on breast cancer cells and animal models. Some recent evidence suggests that cytotoxic activity of mistletoe may be mediated through different mechanisms. These findings provide a good base for clinical trials. Various studies on mistletoe therapy for breast cancer patients revealed similar findings concerning possible benefits on survival time, health-related quality of life (HRQoL), remission rate, and alleviating adverse reactions to conventional therapy. This review provides an overview of the recent findings on preclinical experiments and clinical trials of mistletoe for its cytotoxic and antitumor activity and its effect on HRQoL in breast cancer patients. Moreover, studies investigating molecular and cellular mechanisms underlying antitumor activity of mistletoe are discussed in this paper. The analyzed trials provided evidence that there might be a combination of pharmacological and motivational aspects mediated by the mistletoe extract application which may contribute to the clinical benefit and positive outcome such as improved HRQoL and self-regulation in breast cancer patients.</p> <p><strong>Citation</strong>:<strong> </strong>Marvibaigi, M., Supriyanto, E., Amini, N., Abdul Majid, F. A., &amp; Jaganathan, S. K. (2014). Preclinical and Clinical Effects of Mistletoe against Breast Cancer. <em>BioMed Research International</em>, <em>2014</em>, e785479. <a href="https://doi.org/10.1155/2014/785479" target="_blank">https://doi.org/10.1155/2014/785479</a></p>
dc.description.notesfixed
dc.identifier.citationMarvibaigi, M., Supriyanto, E., Amini, N., Abdul Majid, F. A., & Jaganathan, S. K. (2014). Preclinical and Clinical Effects of Mistletoe against Breast Cancer. BioMed Research International, 2014, e785479. https://doi.org/10.1155/2014/785479
dc.identifier.doihttps://doi.org/10.1155/2014/785479
dc.identifier.externalUrl/library/2020/6/24/preclinical-and-clinical-effects-of-mistletoe-against-breast-cancer
dc.identifier.urihttps://hdl.handle.net/20.500.14430/396
dc.subject.otherMistletoe
dc.subject.otherBreast cancer
dc.subject.otherCancer
dc.titlePreclinical and Clinical Effects of Mistletoe against Breast Cancer
dspace.entity.typePublication
oaire.citation.titleBioMed Res Intl
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01 Anthroposophic medicine (AM), therapies and health
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