Durable clinical remission of a skull metastasis under intralesional Viscum album extract therapy: Case report

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dc.contributor.authorWerthmann, Paul G.
dc.contributor.authorHuber, Roman
dc.contributor.authorKienle, Gunver S.
dc.date.accessioned2024-05-23T18:54:25Z
dc.date.available2024-05-23T18:54:25Z
dc.date.digitized2021-03-14 20:45:01
dc.date.issued2018
dc.description.abstract<p><strong>Background</strong>: Skull metastases are rare, they can eventually cause pain, and can invade the brain. Viscum album extracts (VAEs) are used as an adjuvant treatment in cancer.</p> <p><strong>Methods and Results</strong>: A 68-year-old patient with rectal cancer presented with lung metastases, and metastases to multiple bone sites, the chest wall, and the liver were later identified. Histological examination of one of the bone lesions revealed an additional thyroid carcinoma. An osteolytic parietal bone lesion progressed to a painful metastasis of the skull despite radiotherapy and chemotherapy. The VAEs were applied weekly into the metastasis, followed by pain relief and softening of the lesion. The lesion partially regressed (&gt;50%) after 8 months of continued VAE treatment and remained stable for 2 years.</p> <p><strong>Conclusion</strong>: This case shows a durable clinical remission of a skull metastasis under VAE. Further investigations of intratumoral VAE treatment seem worthwhile—especially in symptomatic skull metastases not responding to radiotherapy or systemic therapies.</p> <p><strong>KEYWORDS</strong>: mistletoe, rectal cancer, skull metastasis, thyroid carcinoma, Viscum album</p> <p><strong>Citation</strong>: Werthmann, P. G., Huber, R., &amp; Kienle, G. S. (2018). Durable clinical remission of a skull metastasis under intralesional Viscum album extract therapy: Case report. <em>Head &amp; Neck</em>, <em>40</em>(7), E77–E81. <a href="https://doi.org/10.1002/hed.25320" target="_blank">https://doi.org/10.1002/hed.25320</a></p>
dc.identifier.citationWerthmann, P. G., Huber, R., & Kienle, G. S. (2018). Durable clinical remission of a skull metastasis under intralesional Viscum album extract therapy: Case report. Head & Neck, 40(7), E77–E81. https://doi.org/10.1002/hed.25320
dc.identifier.doihttps://doi.org/10.1002/hed.25320
dc.identifier.externalUrl/library/2021/3/8/durable-clinical-remission-of-a-skull-metastasis-under-intralesional-viscum-album-extract-therapy-case-report
dc.identifier.urihttps://hdl.handle.net/20.500.14430/439
dc.subject.otherskull metastasis
dc.subject.otherthyroid carcinoma
dc.subject.otherViscum album
dc.subject.otherRectal cancer
dc.subject.otherMistletoe
dc.titleDurable clinical remission of a skull metastasis under intralesional Viscum album extract therapy: Case report
dspace.entity.typePublication
oaire.citation.titleHead & Neck
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01 Anthroposophic medicine (AM), therapies and health
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