Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts
dc.contributor.author | Werthmann, Paul G. | |
dc.contributor.author | Kindermann, Lothar | |
dc.contributor.author | Kienle, Gunver S. | |
dc.date.accessioned | 2024-05-23T18:54:38Z | |
dc.date.available | 2024-05-23T18:54:38Z | |
dc.date.digitized | 2021-03-14 20:51:13 | |
dc.date.issued | 2019 | |
dc.description.abstract | <p><strong>Introduction</strong>: Metastatic renal cell carcinoma has a poor prognosis. Treatment approaches with immunotherapy show promising results in subpopulations. Viscum album extracts – used as an adjunct to cancer treatment – have cytotoxic, apoptogenic, and immune-stimulating properties and show synergistic effects with chemotherapy agents. <strong>Case Report</strong>: A 51-year-old man was diagnosed with metastatic renal cell carcinoma of clear cell histology which was classified as pT3a, N1, M1, G3. Nephrectomy was performed, and the patient received chemoimmunotherapy (interferon-?2a, interleukin-2, fluorouracil, isotretinoin). Additionally, he received V. album extracts as intravenous infusions and subcutaneous injections. One year after surgery, the patient was in complete remission, which is ongoing 18 years after the initial diagnosis. <strong>Discussion</strong>: This case shows an extraordinarily long survival of a metastasized renal cell carcinoma patient under chemoimmunotherapy and fever-inducing V. album extracts. This combined treatment might have synergistically contributed to tumor remission and control. With regard to clinical relevance, further investigations are needed.</p> <p><strong>Keywords:</strong> Renal clear cell carcinoma · Interleukin-2 · Interferon-?2a · 13-cis-Retinoic acid · Viscum album</p> <p><strong>Citation</strong>: Werthmann, P. G., Kindermann, L., & Kienle, G. S. (2019). Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts. <em>Complementary Medicine Research</em>, <em>26</em>(4), 276–279. <a href="https://doi.org/10.1159/000496866" target="_blank">https://doi.org/10.1159/000496866</a></p> | |
dc.description.notes | fixed | |
dc.identifier.citation | Werthmann, P. G., Kindermann, L., & Kienle, G. S. (2019). Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts. Complementary Medicine Research, 26(4), 276–279. https://doi.org/10.1159/000496866 | |
dc.identifier.doi | https://doi.org/10.1159/000496866 | |
dc.identifier.externalUrl | /library/2021/3/7/chemoimmunotherapy-in-advanced-renal-cell-carcinoma-a-case-report-of-a-long-term-survivor-adjunctly-treated-with-viscum-album-extracts | |
dc.identifier.uri | https://hdl.handle.net/20.500.14430/447 | |
dc.subject.other | Renal clear cell carcinoma | |
dc.subject.other | Interleukin-2 | |
dc.subject.other | Interferon-α2a | |
dc.subject.other | 13-cis-Retinoic acid | |
dc.subject.other | Viscum album | |
dc.subject.other | long-term survival | |
dc.title | Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts | |
dspace.entity.type | Publication | |
oaire.citation.title | Complementary Med Research |
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