Werthmann, Paul G.Kindermann, LotharKienle, Gunver S.2024-05-232024-05-232019Werthmann, P. G., Kindermann, L., & Kienle, G. S. (2019). Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts. Complementary Medicine Research, 26(4), 276–279. https://doi.org/10.1159/000496866https://doi.org/10.1159/000496866https://hdl.handle.net/20.500.14430/447<p><strong>Introduction</strong>: Metastatic renal cell carcinoma has a poor prognosis. Treatment approaches with immunotherapy show promising results in subpopulations. Viscum album extracts – used as an adjunct to cancer treatment – have cytotoxic, apoptogenic, and immune-stimulating properties and show synergistic effects with chemotherapy agents. <strong>Case Report</strong>: A 51-year-old man was diagnosed with metastatic renal cell carcinoma of clear cell histology which was classified as pT3a, N1, M1, G3. Nephrectomy was performed, and the patient received chemoimmunotherapy (interferon-?2a, interleukin-2, fluorouracil, isotretinoin). Additionally, he received V. album extracts as intravenous infusions and subcutaneous injections. One year after surgery, the patient was in complete remission, which is ongoing 18 years after the initial diagnosis. <strong>Discussion</strong>: This case shows an extraordinarily long survival of a metastasized renal cell carcinoma patient under chemoimmunotherapy and fever-inducing V. album extracts. This combined treatment might have synergistically contributed to tumor remission and control. With regard to clinical relevance, further investigations are needed.</p> <p><strong>Keywords:</strong> Renal clear cell carcinoma · Interleukin-2 · Interferon-?2a · 13-cis-Retinoic acid · Viscum album</p> <p><strong>Citation</strong>: Werthmann, P. G., Kindermann, L., &amp; Kienle, G. S. (2019). Chemoimmunotherapy in Advanced Renal Cell Carcinoma: A Case Report of a Long-Term Survivor Adjunctly Treated with Viscum album Extracts. <em>Complementary Medicine Research</em>, <em>26</em>(4), 276–279. <a href="https://doi.org/10.1159/000496866" target="_blank">https://doi.org/10.1159/000496866</a></p>Renal clear cell carcinomaInterleukin-2Interferon-α2a13-cis-Retinoic acidViscum albumlong-term survival/library/2021/3/7/chemoimmunotherapy-in-advanced-renal-cell-carcinoma-a-case-report-of-a-long-term-survivor-adjunctly-treated-with-viscum-album-extracts